Association of Spirochetes and Lyme Disease with Morgellons Disease

Buddhini Dolapihilla; Dulara Mahen Elapatha; Jase Grimm

doi:10.18034/ajase.v10i1.21

Authors

Buddhini Dolapihilla Faculty of Medicine, University of Colombo, Sri Lanka
Dulara Mahen Elapatha Faculty of Medicine, University of Colombo, Sri Lanka
Jase Grimm Uncommon Fruit LLC, 1801 E Tahquitz Canyon Way Suite 100, Palm Springs, CA 92262, USA

Keywords:

Morgellons Disease

Lyme disease

Filaments

Cutaneous Lesions

Spirochetes

Abstract

Morgellons Disease (MD) is a multisystem disorder with a primary symptom characterized by emerging of small fibres from the skin. For years, many doctors thought MD is a psychiatric disorder and treated the patients with antipsychotic drugs, behavioural therapy and counselling. However, recent studies suggest that MD is a completely different entity from psychiatric disorders. Morgellons pathophysiology remains a mystery even now. It was previously considered to be a delusional disorder due to its similarity to delusions of parasitosis or delusional infestation described many years ago. This constellation of symptoms has not been well studied in different populations, however, a study in North California found a prevalence of 3.65 per 100,000 for MD, with Caucasian and female predominance.

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References

Accordino RE, Engler D, Ginsburg IH, Koo J. Morgellons disease? Dermatologic Therapy. 2008;21(1):8–12. DOI: https://doi.org/10.1111/j.1529-8019.2008.00164.x

Driscoll MS, Rothe MJ, Grant-Kels JM, Hale MS. Delusional parasitosis: a dermatologic, psychiatric, and pharmacologic approach. J Am Acad Dermatol. 1993 Dec;29(6):1023–33. DOI: https://doi.org/10.1016/0190-9622(93)70284-Z

Lyell A. Delusions of parasitosis. J Am Acad Dermatol. 1983 Jun;8(6):895–7. DOI: https://doi.org/10.1016/S0190-9622(83)80024-3

Pearson ML, Selby JV, Katz KA, Cantrell V, Braden CR, Parise ME, et al. Clinical, Epidemiologic, Histopathologic and Molecular Features of an Unexplained Dermopathy. PLoS One. 2012 Jan 25;7(1):e29908. DOI: https://doi.org/10.1371/journal.pone.0029908

Middelveen MJ, Burugu D, Poruri A, Burke J, Mayne PJ, Sapi E, et al. Association of spirochetal infection with Morgellons disease. F1000Res. 2013 Jan 28;2:25. DOI: https://doi.org/10.12688/f1000research.2-25.v1

Middelveen MJ, Bandoski C, Burke J, Sapi E, Filush KR, Wang Y, et al. Exploring the association between Morgellons disease and Lyme disease: identification of Borrelia burgdorferi in Morgellons disease patients. BMC Dermatol. 2015 Feb 12;15(1):1. DOI: https://doi.org/10.1186/s12895-015-0023-0

Middelveen MJ, Stricker RB. Filament formation associated with spirochetal infection: a comparative approach to Morgellons disease. Clin Cosmet Investig Dermatol. 2011 Nov 14;4:167–77. DOI: https://doi.org/10.2147/CCID.S26183

Savely VR, Stricker RB. Morgellons disease: Analysis of a population with clinically confirmed microscopic subcutaneous fibers of unknown etiology. Clin Cosmet Investig Dermatol. 2010 May 13;3:67–78. DOI: https://doi.org/10.2147/CCID.S9520

Chu C. Morgellons Disease—Dredged Up From History and Customized. JAMA Dermatology. 2018 Apr 1;154(4):451–451. DOI: https://doi.org/10.1001/jamadermatol.2017.6393

Kellett CE. Sir Thomas Browne and the Disease Called the Morgellons. Ann Med Hist. 1935 Sep;7(5):467–79.

The Morgellons Research Foundation (MRF) [Internet]. Morgellons Disease ? [cited 2021 Aug 13]. Available from: https://www.morgellons.org/

Harvey WT, Bransfield RC, Mercer DE, Wright AJ, Ricchi RM, Leitao MM. Morgellons disease, illuminating an undefined illness: a case series. J Med Case Reports. 2009 Jul 1;3:8243. DOI: https://doi.org/10.4076/1752-1947-3-8243

Fesler MC, Middelveen MJ, Stricker RB. Clinical evaluation of Morgellons disease in a cohort of North American patients. Dermatology Reports [Internet]. 2018 Apr 24 [cited 2021 Aug 9];10(1). Available from: https://www.pagepress.org/journals/index.php/dr/article/view/7660 DOI: https://doi.org/10.4081/dr.2018.7660

Ohn J, Park SY, Moon J, Choe YS, Kim KH. Morgellons Disease. Ann Dermatol. 2017 Apr;29(2):223–5. DOI: https://doi.org/10.5021/ad.2017.29.2.223

Middelveen MJ, Fesler MC, Stricker RB. History of Morgellons disease: from delusion to definition. Clin Cosmet Investig Dermatol. 2018 Feb 9;11:71–90. DOI: https://doi.org/10.2147/CCID.S152343

Middelveen MJ, Martinez RM, Fesler MC, Sapi E, Burke J, Shah JS, et al. Classification and Staging of Morgellons Disease: Lessons from Syphilis. CCID. 2020 Feb 7;13:145–64. DOI: https://doi.org/10.2147/CCID.S239840

Savely VR, Leitao MM, Stricker RB. The mystery of Morgellons disease: infection or delusion? Am J Clin Dermatol. 2006;7(1):1–5. DOI: https://doi.org/10.2165/00128071-200607010-00001

Mayne P, English JS, Kilbane EJ, Burke JM, Middelveen MJ, Stricker RB. Morgellons: a novel dermatological perspective as the multisystem infective disease borreliosis. F1000Res. 2013 May 1;2:118. DOI: https://doi.org/10.12688/f1000research.2-118.v1

González-Ponce M, Morales-Vargas AT, Segoviano-Garfias JN. Metallopharmaceuticals as possible treatment for an uncharacterized parasitosis. 2015;5(8):5.

Stricker R, Savely V, Zaltsman A, Citovsky V. Contribution of Agrobacterium to Morgellons Disease.: 287. Journal of Investigative Medicine. 2007 Jan 1;55:S123. DOI: https://doi.org/10.1097/00042871-200701010-00294

Middelveen MJ, Sapi E, Burke J, Filush KR, Franco A, Fesler MC, et al. Persistent Borrelia Infection in Patients with Ongoing Symptoms of Lyme Disease. Healthcare. 2018 Jun;6(2):33. DOI: https://doi.org/10.3390/healthcare6020033

Rudenko N, Golovchenko M, Kybicova K, Vancova M. Metamorphoses of Lyme disease spirochetes: phenomenon of Borrelia persisters. Parasites & Vectors. 2019 May 16;12(1):237. DOI: https://doi.org/10.1186/s13071-019-3495-7

Reid EE, Lio PA. Successful Treatment of Morgellons Disease With Pimozide Therapy. Arch Dermatol [Internet]. 2010 Oct 1 [cited 2021 Aug 12];146(10). Available from: http://archderm.jamanetwork.com/article.aspx?doi=10.1001/archdermatol.2010.276 DOI: https://doi.org/10.1001/archdermatol.2010.276

Koblenzer CS. Pimozide at least as safe and perhaps more effective than olanzapine for treatment of Morgellons disease. Arch Dermatol. 2006 Oct;142(10):1364. DOI: https://doi.org/10.1001/archderm.142.10.1364-b

Middelveen MJ, Stricker RB. Morgellons disease: a filamentous borrelial dermatitis. Int J Gen Med. 2016 Oct 14;9:349–54. DOI: https://doi.org/10.2147/IJGM.S116608

Lee CS, Accordino R, Howard J, Koo J. Psychopharmacology in dermatology. Dermatologic Therapy. 2008;21(1):69–82. DOI: https://doi.org/10.1111/j.1529-8019.2008.00172.x

Mohandas P, Bewley A, Taylor R. Morgellons disease: experiences of an integrated multidisciplinary dermatology team to achieve positive outcomes. Journal of Dermatological Treatment. 2018 Feb 17;29(2):208–13. DOI: https://doi.org/10.1080/09546634.2017.1349868